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Flumazenil is contraindicated in patients: With known hypersensitivity to flumazenil or to any of the excipients.
Patients receiving benzodiazepines for control of a potentially life-threatening condition (e.g. control of intracranial pressure or status epilepticus).
In mixed intoxications with benzodiazepines and tricylic and/ or tetracyclic antidepressants, the toxicity of the antidepressants can be masked by protective benzodiazepine effects.
In the presence of autonomic (anticholinergic), neurological (motor abnormalities) or cardiovascular symptoms of severe intoxication with tricyclics/tetracyclics, flumazenil should not be used to reverse the benzodiazepine effect.
